Cytokines in oncolytic virotherapy

Jonathan G Pol; Samuel T Workenhe; Prathyusha Konda; Shashi Gujar; Guido Kroemer

doi:10.1016/j.cytogfr.2020.10.007

Cytokines in oncolytic virotherapy

Cytokine Growth Factor Rev. 2020 Dec:56:4-27. doi: 10.1016/j.cytogfr.2020.10.007. Epub 2020 Nov 2.

Authors

Jonathan G Pol¹, Samuel T Workenhe², Prathyusha Konda³, Shashi Gujar⁴, Guido Kroemer⁵

Affiliations

¹ Centre de Recherche des Cordeliers, Equipe 11 labellisée par la Ligue Nationale contre le Cancer, INSERM, Sorbonne Université, Université de Paris, Paris, France; Gustave Roussy Cancer Campus, Metabolomics and Cell Biology Platforms, Villejuif, France. Electronic address: pol_jonathan@yahoo.fr.
² Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
³ Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.
⁴ Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada; Department of Pathology, Dalhousie University, Halifax, NS, Canada; Department of Biology, Dalhousie University, Halifax, NS, Canada; Beatrice Hunter Cancer Research Institute, Halifax, NS, Canada.
⁵ Centre de Recherche des Cordeliers, Equipe 11 labellisée par la Ligue Nationale contre le Cancer, INSERM, Sorbonne Université, Université de Paris, Paris, France; Gustave Roussy Cancer Campus, Metabolomics and Cell Biology Platforms, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China; Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden. Electronic address: kroemer@orange.fr.

PMID: 33183957
DOI: 10.1016/j.cytogfr.2020.10.007

Abstract

Tumors represent a hostile environment for the effector cells of cancer immunosurveillance. Immunosuppressive receptors and soluble or membrane-bound ligands are abundantly exposed and released by malignant entities and their stromal accomplices. As a consequence, executioners of antitumor immunity inefficiently navigate across cancer tissues and fail to eliminate malignant targets. By inducing immunogenic cancer cell death, oncolytic viruses profoundly reshape the tumor microenvironment. They trigger the local spread of danger signals and tumor-associated (as well as viral) antigens, thus attracting antigen-presenting cells, promoting the activation and expansion of lymphocytic populations, facilitating their infiltration in the tumor bed, and reinvigorating cytotoxic immune activity. The present review recapitulates key chemokines, growth factors and other cytokines that orchestrate this ballet of antitumoral leukocytes upon oncolytic virotherapy.

Keywords: Chemokines; Growth factors; Interferons; Interleukins; Oncolytic virus.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cytokines
Humans
Neoplasms* / therapy
Oncolytic Virotherapy*
Oncolytic Viruses*
Tumor Microenvironment

Substances

Cytokines