Tramadol Treatment for Chemotherapy-induced Mucositis Pain in Children

J Pediatr Hematol Oncol. 2022 Mar 1;44(2):e487-e492. doi: 10.1097/MPH.0000000000002003.

Abstract

Mucositis, a painful and debilitating condition, is a common side effect of chemotherapy. The role of tramadol in the treatment of mucositis in pediatric patients has not yet been determined. In this retrospective study, we evaluate whether tramadol as single agent achieved a reduction of pain intensity among oncologic children admitted for mucositis. In total, 34 of 54 (63%) episodes were treated with tramadol alone and achieved adequate pain relief. Tramadol's side effects were mild and manageable.

MeSH terms

  • Analgesics, Opioid
  • Antineoplastic Agents* / therapeutic use
  • Child
  • Humans
  • Mucositis* / chemically induced
  • Mucositis* / drug therapy
  • Pain / chemically induced
  • Pain / drug therapy
  • Retrospective Studies
  • Tramadol* / adverse effects

Substances

  • Analgesics, Opioid
  • Antineoplastic Agents
  • Tramadol