Construction of Protein Expression Network

Nor Afiqah-Aleng; Zeti-Azura Mohamed-Hussein

doi:10.1007/978-1-0716-0822-7_10

Construction of Protein Expression Network

Methods Mol Biol. 2021:2189:119-132. doi: 10.1007/978-1-0716-0822-7_10.

Authors

Nor Afiqah-Aleng^{1

2}, Zeti-Azura Mohamed-Hussein^{3

4}

Affiliations

¹ Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia.
² Institute of Marine Biotechnology, Universiti Malaysia Terengganu, Kuala Nerus, Terengganu, Malaysia.
³ Institute of Systems Biology (INBIOSIS), Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia. zeti.hussein@ukm.edu.my.
⁴ Department of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia. zeti.hussein@ukm.edu.my.

PMID: 33180298
DOI: 10.1007/978-1-0716-0822-7_10

Abstract

In this post-genomic era, protein network can be used as a complementary way to shed light on the growing amount of data generated from current high-throughput technologies. Protein network is a powerful approach to describe the molecular mechanisms of the biological events through protein-protein interactions. Here, we describe the computational methods used to construct the protein network using expression data. We provide a list of available tools and databases that can be used in constructing the network.

Keywords: Gene expression; PPI network; Protein expression; Protein network; Protein–protein interaction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Computational Biology*
Databases, Protein*
Protein Interaction Mapping*
Protein Interaction Maps*