Mitochondria-Targeting Oxygen-Sufficient Perfluorocarbon Nanoparticles for Imaging-Guided Tumor Phototherapy

Sijie Chen; Biying Huang; Wenjing Pei; Long Wang; Yan Xu; Chengcheng Niu

doi:10.2147/IJN.S281649

Mitochondria-Targeting Oxygen-Sufficient Perfluorocarbon Nanoparticles for Imaging-Guided Tumor Phototherapy

Int J Nanomedicine. 2020 Nov 5:15:8641-8658. doi: 10.2147/IJN.S281649. eCollection 2020.

Authors

Sijie Chen^{1

2

3}, Biying Huang^{1

2}, Wenjing Pei^{1

2}, Long Wang⁴, Yan Xu^{1

2}, Chengcheng Niu^{1

2}

Affiliations

¹ Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China.
² Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People's Republic of China.
³ Department of Ultrasound Diagnosis, Changsha Central Hospital, Nanhua University, Changsha, Hunan 410014, People's Republic of China.
⁴ Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People's Republic of China.

Abstract

Background: Although photothermal therapy (PTT) and photodynamics therapy (PDT) have both made excellent progress in tumor therapy, the effectiveness of using PTT or PDT alone is dissatisfactory due to the limitations of the penetration depth in PTT and the hypoxic microenvironment of tumors for PDT. Combination phototherapy has currently become a burgeoning cancer treatment.

Methods and materials: In this work, a mitochondria-targeting liquid perfluorocarbon (PFC)-based oxygen delivery system was developed for the synergistic PDT/photothermal therapy (PTT) of cancer through image guiding.

Results: Importantly, these nanoparticles (NPs) can effectively and accurately accumulate in the target tumor via the enhanced permeability and retention (EPR) effect.

Conclusion: This approach offers a novel technique to achieve outstanding antitumor efficacy by an unprecedented design with tumor mitochondria targeting, oxygen delivery, and synergistic PDT/PTT with dual-imaging guidance.

Keywords: IR780; mitochondria-targeting; perfluorocarbon; photodynamic therapy; photothermal therapy.

MeSH terms

Animals
Cell Line, Tumor
Drug Delivery Systems
Female
Fluorocarbons / chemistry*
Humans
Membrane Potential, Mitochondrial / drug effects
Mice, Inbred BALB C
Mitochondria / drug effects*
Mitochondria / pathology
Nanoparticles / administration & dosage*
Nanoparticles / chemistry
Neoplasms, Experimental / diagnostic imaging
Neoplasms, Experimental / pathology
Neoplasms, Experimental / therapy*
Oxygen / administration & dosage*
Oxygen / chemistry
Oxygen / pharmacokinetics
Phototherapy / methods*
Singlet Oxygen / pharmacokinetics
Xenograft Model Antitumor Assays

Substances

Fluorocarbons
Singlet Oxygen
Oxygen

Grants and funding

This project was funded by the National Natural Science Foundation of China (Grant No. 81974267 and 81601883), Hunan Provincial Natural Science Foundation of China (Grant 2018JJ3861) and Hunan Provincial Health Commission Research Foundation Project (B2019166).