Desaturation and heme elevation during COVID-19 infection: A potential prognostic factor of heme oxygenase-1

J Microbiol Immunol Infect. 2021 Feb;54(1):113-116. doi: 10.1016/j.jmii.2020.10.001. Epub 2020 Oct 16.

Abstract

Increased heme levels, anemia, and desaturation occur during infection. We aimed to compare the levels of heme, heme oxygenase-1 (HO-1), ferritin, and bilirubin in coronavirus disease 2019 (COVID-19) patients at different saturation levels. Heme and HO-1 enzyme levels significantly increased in the low SpO2 group, but further studies are required.

Keywords: COVID-19; Heme; Heme oxygenase-1; SARS-CoV-2.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Bilirubin / blood
  • COVID-19 / blood
  • COVID-19 / enzymology
  • COVID-19 / metabolism*
  • Female
  • Ferritins / blood
  • Heme / metabolism*
  • Heme Oxygenase-1 / blood*
  • Humans
  • Male
  • Middle Aged
  • Oximetry
  • Prognosis
  • SARS-CoV-2 / isolation & purification

Substances

  • Heme
  • Ferritins
  • HMOX1 protein, human
  • Heme Oxygenase-1
  • Bilirubin