Recent Development of Novel HDAC6 Isoform-selective Inhibitors

Curr Med Chem. 2021;28(21):4133-4151. doi: 10.2174/0929867327666201111142653.

Abstract

As an important post-transcription modification, histone deacetylation plays significant roles in chromatin remodeling and gene expression. The aberrant modification of histone deacetylation leads to various diseases. As a critical member of histone deacetylase (HDAC), HDAC6 serves as a key modulator in many physiological processes. Abnormal expression of HDAC6 gives rise to cancer, neurodegeneration and other diseases. Here, we have reviewed recent advances in physiological, protein structure and development of HDAC6 selective inhibitors.

Keywords: HDAC6; cancer; histone deacetylation.; post-transcription modification; selective inhibitor; structure.

Publication types

  • Review

MeSH terms

  • Histone Deacetylase 6 / antagonists & inhibitors*
  • Histone Deacetylase Inhibitors* / pharmacology
  • Humans
  • Neoplasms* / drug therapy
  • Protein Isoforms / genetics

Substances

  • Histone Deacetylase Inhibitors
  • Protein Isoforms
  • HDAC6 protein, human
  • Histone Deacetylase 6