Role of Montelukast as Monotherapy in Improving Quality of Life of an Asthmatic Patient in Pakistan

Ankeeta Kumari; Mishal Ejaz; Khurram Anis; Sumeet Kumar; Besham Kumar; Sidra Memon

doi:10.7759/cureus.10841

Role of Montelukast as Monotherapy in Improving Quality of Life of an Asthmatic Patient in Pakistan

Cureus. 2020 Oct 7;12(10):e10841. doi: 10.7759/cureus.10841.

Authors

Ankeeta Kumari¹, Mishal Ejaz², Khurram Anis³, Sumeet Kumar⁴, Besham Kumar⁵, Sidra Memon⁶

Affiliations

¹ Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, PAK.
² Internal Medicine, Ziauddin University, Karachi, PAK.
³ Gastroenterology/Hepatology, Pakistan Kidney and Liver Institute, Lahore, PAK.
⁴ Internal Medicine, Chandka Medical College Hospital, Larkana, PAK.
⁵ Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.
⁶ Internal Medicine, Jinnah Sindh Medical University, Karachi, PAK.

Abstract

Introduction: Uncontrolled and inadequately managed asthma substantially reduces Quality of Life (QOL) and can lead to premature death. The aim of this study is to understand the role of montelukast in improving quality of life in asthmatic patients by comparing it with placebo.

Methods: This prospective, single-arm, interventional study was conducted from September 2019 to February 2020 in the pulmonology outpatient department of a tertiary care hospital in Pakistan. All patients were prescribed montelukast (10 mg once daily).

Results: At day 28, participants had a higher score on the Asthma Quality of Life Questionnaire-Standard (AQLQ-S) overall and in all sub-domains compared to day 0. The improvement was significant overall and for the sub-domains of symptoms, activity limitations, and environmental stimuli.

Conclusion: Montelukast has an effective role in asthma control as well as in improving the quality of life in the Pakistani population.

Keywords: montelukast; pakistan; quality of life.