Glucocorticoid-induced cardiomyopathy: unexpected conclusion

BMJ Case Rep. 2020 Nov 9;13(11):e237173. doi: 10.1136/bcr-2020-237173.

Abstract

Glucocorticoid excess is an under-recognised cause of cardiovascular adverse effects. The sources can be either endogenous (Cushing's syndrome) or exogenous (Anabolic steroid abuse). Cardiovascular complications due to excess glucocorticoid includes hypertension, left ventricular hypertrophy, myocardial infarction, and heart failure. Although anabolic steroid-induced cardiomyopathy is a well-recognised phenomenon, endogenous corticosteroid-induced cardiomyopathy and heart failure are rarely reported sequelae of glucocorticoid excess in the body. We report a glucocorticoid-induced dilated cardiomyopathy in a 26-year-old African-American man with cushingoid features and symptomatic heart failure.

Keywords: adrenal disorders; drugs: endocrine system; heart failure.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cardiomyopathies / chemically induced*
  • Cardiomyopathies / diagnosis
  • Cardiotoxicity
  • Cushing Syndrome / drug therapy*
  • Diagnosis, Differential
  • Echocardiography, Doppler, Color
  • Electrocardiography
  • Glucocorticoids / adverse effects*
  • Glucocorticoids / therapeutic use
  • Humans
  • Male
  • Tomography, X-Ray Computed

Substances

  • Glucocorticoids