Association of Hearing Loss With Neuropsychiatric Symptoms in Older Adults With Cognitive Impairment

Alexander S Kim; Emmanuel E Garcia Morales; Halima Amjad; Valerie T Cotter; Frank R Lin; Constantine G Lyketsos; Milap A Nowrangi; Sara K Mamo; Nicholas S Reed; Sevil Yasar; Esther S Oh; Carrie L Nieman

doi:10.1016/j.jagp.2020.10.002

Association of Hearing Loss With Neuropsychiatric Symptoms in Older Adults With Cognitive Impairment

Am J Geriatr Psychiatry. 2021 Jun;29(6):544-553. doi: 10.1016/j.jagp.2020.10.002. Epub 2020 Oct 14.

Authors

Affiliations

¹ Johns Hopkins University School of Medicine (ASK), Baltimore, MD; Cochlear Center for Hearing and Public Health (ASK, EEGM, FRL, NSR, ESO, CLN), Baltimore, MD.
² Cochlear Center for Hearing and Public Health (ASK, EEGM, FRL, NSR, ESO, CLN), Baltimore, MD.
³ Division of Geriatric Medicine and Gerontology (HA, SY, ESO), Johns Hopkins University School of Medicine, Baltimore, MD.
⁴ Johns Hopkins University School of Nursing (VTC, ESO), Baltimore, MD.
⁵ Cochlear Center for Hearing and Public Health (ASK, EEGM, FRL, NSR, ESO, CLN), Baltimore, MD; Department of Otolaryngology-Head and Neck Surgery (FRL, CLN), Johns Hopkins University School of Medicine, Baltimore, MD.
⁶ Department of Psychiatry and Behavioral Sciences (CGL, MAN, ESO), Johns Hopkins Bayview and Johns Hopkins University, Baltimore, MD.
⁷ Department of Communication Disorders (SKM), University of Massachusetts Amherst, Amherst, MD.
⁸ Cochlear Center for Hearing and Public Health (ASK, EEGM, FRL, NSR, ESO, CLN), Baltimore, MD; Department of Epidemiology (NSR), Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
⁹ Cochlear Center for Hearing and Public Health (ASK, EEGM, FRL, NSR, ESO, CLN), Baltimore, MD; Division of Geriatric Medicine and Gerontology (HA, SY, ESO), Johns Hopkins University School of Medicine, Baltimore, MD; Johns Hopkins University School of Nursing (VTC, ESO), Baltimore, MD; Department of Psychiatry and Behavioral Sciences (CGL, MAN, ESO), Johns Hopkins Bayview and Johns Hopkins University, Baltimore, MD.
¹⁰ Cochlear Center for Hearing and Public Health (ASK, EEGM, FRL, NSR, ESO, CLN), Baltimore, MD; Department of Otolaryngology-Head and Neck Surgery (FRL, CLN), Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: cnieman1@jhmi.edu.

Abstract

Neuropsychiatric symptoms (NPS) in persons with dementia (PWD) are common and can lead to poor outcomes, such as institutionalization and mortality, and may be exacerbated by sensory loss. Hearing loss is also highly prevalent among older adults, including PWD.

Objective: This study investigated the association between hearing loss and NPS among community- dwelling patients from a tertiary memory care center.

Design, setting, and participants: Participants of this cross-sectional study were patients followed at the Johns Hopkins Memory and Alzheimer's Treatment Center who underwent audiometric testing during routine clinical practice between October 2014 and January 2017.

Outcome measurements: Included measures were scores on the Neuropsychiatric Inventory-Questionnaire and the Cornell Scale for Depression in Dementia.

Results: Participants (n = 101) were on average 76 years old, mostly female and white, and had a mean Mini-Mental State Examination score of 23. We observed a positive association between audiometric hearing loss and the number of NPS (b = 0.7 per 10 dB; 95% confidence interval [CI]: 0.2, 1.1; t = 2.86; p = 0.01; df = 85), NPS severity (b = 1.3 per 10 dB; 95% CI: 0.4, 2.5; t = 2.13; p = 0.04; df = 80), and depressive symptom severity (b = 1.5 per 10 dB; 95% CI: 0.4, 2.5; t = 2.83; p = 0.01; df = 89) after adjustment for demographic and clinical characteristics. Additionally, the use of hearing aids was inversely associated with the number of NPS (b = -2.09; 95% CI -3.44, -0.75; t = -3.10; p = 0.003; df = 85), NPS severity (b = -3.82; 95% CI -7.19, -0.45; t = -2.26; p = 0.03; df = 80), and depressive symptom severity (b = -2.94; 95% CI: -5.93, 0.06; t = 1.70; p = 0.05; df = 89).

Conclusion: Among patients at a memory clinic, increasing severity of hearing loss was associated with a greater number of NPS, more severe NPS, and more severe depressive symptoms, while hearing aid use was associated with fewer NPS, lower severity, and less severe depressive symptoms. Identifying and addressing hearing loss may be a promising, low-risk, non-pharmacological intervention in preventing and treating NPS.

Keywords: Hearing loss; cognitive impairment; dementia; hearing care; neuropsychiatric symptoms.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cognitive Dysfunction* / complications
Cognitive Dysfunction* / epidemiology
Cross-Sectional Studies
Female
Hearing Aids*
Hearing Loss* / complications
Hearing Loss* / epidemiology
Humans
Male
Neuropsychological Tests

Abstract

Publication types

MeSH terms

Grants and funding