Introducing polymer conductance in diagnostically relevant transduction

Abstract

In this work we demonstrate that an impedance derived capacitance method is able to cleanly resolve the resonant conductance characteristics of an electrode-confined polymer film. In decorating the film with receptors, this conductance is thereafter modulated by the capturing of specific targets, demonstrated herein with C-reactive protein. This entirely reagentless and single step marker quantification is relevant to the drive of moving assays to a scaleable format requiring minimal user intervention.

Keywords: Biosensors; C-reactive protein; Molecular scale conductance; Point-of-care; Reagentless.