A decade of cell death studies: Breathing new life into necroptosis

Imran Khan; Abdelrahman Yousif; Mikhail Chesnokov; Linda Hong; IIana Chefetz

doi:10.1016/j.pharmthera.2020.107717

A decade of cell death studies: Breathing new life into necroptosis

Pharmacol Ther. 2021 Apr:220:107717. doi: 10.1016/j.pharmthera.2020.107717. Epub 2020 Oct 24.

Authors

Imran Khan¹, Abdelrahman Yousif², Mikhail Chesnokov¹, Linda Hong³, IIana Chefetz⁴

Affiliations

¹ The Hormel Institute, University of Minnesota, Austin, MN, USA.
² The Hormel Institute, University of Minnesota, Austin, MN, USA; Department of Obstetrics and Gyneacology, Hurley Medical Center, Flint, MI, USA.
³ Loma Linda University School of Medicine, Loma Linda, CA, USA.
⁴ The Hormel Institute, University of Minnesota, Austin, MN, USA; Masonic Cancer Center, Minneapolis, MN, USA; Stem Cell Institute, Minneapolis, MN, USA; Obstetrics, Gynecology and Women's Health, Minneapolis, MN, USA. Electronic address: ichefetz@umn.edu.

PMID: 33164841
DOI: 10.1016/j.pharmthera.2020.107717

Abstract

Programmed cell death (PCD) has been a major area of constantly growing interest over the last three decades. Originally, apoptosis was considered the only mechanistic pathway for PCD, but recently several different pathways (i.e., necroptosis, pyroptosis, ferroptosis) have emerged as important in both normal and pathological conditions. This review focuses on programmed cell necrosis (i.e., necroptosis) as a promising research direction that will help us in understanding the molecular and cellular processes behind different pathological conditions, such as chronic inflammation, neurodegeneration, and cardiovascular diseases. In addition, we discuss natural and chemical compounds and novel targeted therapies triggering necroptosis to induce cell death in cancer cells to overcome chemoresistance.

Keywords: Cancer; Cardiovascular disorders; Cell death; Cell programmed necrosis; MLKL; Necroptosis; Neurodegenerative diseases; RIPK1; RIPK3.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Apoptosis
Cell Death*
Humans
Necroptosis*
Necrosis