Methyl-Coenzyme M Reductase and Its Post-translational Modifications

Hao Chen; Qinglei Gan; Chenguang Fan

doi:10.3389/fmicb.2020.578356

Methyl-Coenzyme M Reductase and Its Post-translational Modifications

Front Microbiol. 2020 Oct 9:11:578356. doi: 10.3389/fmicb.2020.578356. eCollection 2020.

Authors

Hao Chen¹, Qinglei Gan², Chenguang Fan^{1

2}

Affiliations

¹ Cell and Molecular Biology Program, University of Arkansas, Fayetteville, AR, United States.
² Department of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, United States.

Abstract

The methyl-coenzyme M reductase (MCR) is a central enzyme in anaerobic microbial methane metabolism, which consists of methanogenesis and anaerobic oxidation of methane (AOM). MCR catalyzes the final step of methanogenesis and the first step of AOM to achieve the production and oxidation of methane, respectively. Besides a unique nickel tetrahydrocorphinoid (coenzyme F430), MCR also features several unusual post-translational modifications (PTMs), which are assumed to play important roles in regulating MCR functions. However, only few studies have been implemented on MCR PTMs. Therefore, to recapitulate current knowledge and prospect future studies, this review summarizes and discusses studies on MCR and its PTMs.

Keywords: anaerobic methanotrophic archaea; anaerobic oxidation of methane; methanogenesis; methanogenic archaea; methyl-coenzyme M reductase; methylation; post-translational modification; thioamidation.

Publication types

Review