Cell Competition Boosts Clonal Evolution and Hypoxic Selection in Cancer

Esha Madan; Maria Leonor Peixoto; Peter Dimitrion; Timothy D Eubank; Michail Yekelchyk; Sarmistha Talukdar; Paul B Fisher; Qing-Sheng Mi; Eduardo Moreno; Rajan Gogna

doi:10.1016/j.tcb.2020.10.002

Cell Competition Boosts Clonal Evolution and Hypoxic Selection in Cancer

Trends Cell Biol. 2020 Dec;30(12):967-978. doi: 10.1016/j.tcb.2020.10.002. Epub 2020 Nov 4.

Authors

Affiliations

¹ Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal.
² Center for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health System, Detroit, MI, USA; Immunology Research Program, Henry Ford Cancer Institute, Henry Ford Health System, Detroit, MI, USA; Department of Biochemistry, Microbiology and Immunology, Wayne State University Medical School, Detroit, MI, USA.
³ In Vivo Multifunctional Magnetic Resonance Center, Robert C. Byrd Health Sciences Center, West Virginia University, Morgantown, WV, USA; Department of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, WV, USA.
⁴ Department of Cardiac Development and Remodeling, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.
⁵ Department of Human and Molecular Genetics, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA; VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Richmond, VA, USA.
⁶ Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal. Electronic address: eduardo.moreno@research.fchampalimaud.org.
⁷ Champalimaud Centre for the Unknown, 1400-038 Lisbon, Portugal. Electronic address: rajan.gogna@research.fchampalimaud.org.

PMID: 33160818
DOI: 10.1016/j.tcb.2020.10.002

Abstract

The comparison of fitness between cells leads to the elimination of less competent cells in the presence of more competent neighbors via cell competition (CC). This phenomenon has been linked with several cancer-related genes and thus may play an important role in cancer. Various processes are involved in the regulation of tumor initiation and growth, including tumor hypoxia, clonal stem cell selection, and immune cell response, all of which have been recently shown to have a potential connection with the mechanisms involved in CC. This review aims to unravel the relation between these processes and competitive cell interactions and how this affects disease progression.

Keywords: Flower; Myc; cell competition; hypoxic environment; p53; tumor heterogeneity.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Competition*
Clonal Evolution*
Humans
Lymph Nodes / pathology
Stem Cells / metabolism
Tumor Hypoxia*
Tumor Microenvironment