Single nucleotide polymorphisms within NFKBIA are associated with nasopharyngeal carcinoma susceptibility in Chinese Han population

Hanyi Zhang; Siyao Deng; Jiayu Zhang; Guiquan Zhu; Jie Zhou; Wenjing Ye; Qingwei Wang; Yi Wang; Bingwen Zou; Peng Zhang; Shichuan Zhang; Jinyi Lang; Shun Lu

doi:10.1016/j.cyto.2020.155356

Single nucleotide polymorphisms within NFKBIA are associated with nasopharyngeal carcinoma susceptibility in Chinese Han population

Cytokine. 2021 Feb:138:155356. doi: 10.1016/j.cyto.2020.155356. Epub 2020 Nov 5.

Authors

Hanyi Zhang¹, Siyao Deng², Jiayu Zhang², Guiquan Zhu³, Jie Zhou¹, Wenjing Ye², Qingwei Wang⁴, Yi Wang⁴, Bingwen Zou⁵, Peng Zhang¹, Shichuan Zhang¹, Jinyi Lang⁶, Shun Lu⁷

Affiliations

¹ Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
² School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
³ Department of Radiological Protection, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, China.
⁴ Sichuan Provincial Key Laboratory for Disease Gene Study and Department of Laboratory Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
⁵ Department of Thoracic Oncology, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Chengdu, China.
⁶ Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China; Department of Radiological Protection, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, China.
⁷ Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China; Department of Radiological Protection, Radiation Oncology Key Laboratory of Sichuan Province, Chengdu, China. Electronic address: lushun1982@live.cn.

PMID: 33160813
DOI: 10.1016/j.cyto.2020.155356

Abstract

Genes involved in latent membrane protein 1 (LMP1) signaling pathways have been suggested to play an important role in nasopharyngeal carcinogenesis. We investigated potentially functional genetic variants associated with the risk of nasopharyngeal carcinoma (NPC) in genes involved in the LMP1 signaling pathway. Altogether, 73 single nucleotide polymorphisms (SNPs) with MAF ≥ 10% were located within the regions of interest of the four genes TRAF3, NFKBIA, CHUK and MAP2K4. From these, 10 SNPs were selected for genotyping based on LD (r² ≥ 0.80) in a hospital-based case-control study of 332 NPC cases and 585 healthy controls from the Chinese Han population. Minor allele carriers of the promoter SNP rs2233409 in NFKBIA, had an increased risk of NPC (AA vs GG: OR 7.14, 95%CI, 1.08-34.18, P = 0.04, dominant model). Based on the results, we concluded that rs2233409 polymorphism in NFKBIA may be moderately associated with the risk of NPC. Further studies with larger independent samples and functional analysis are needed to verify our results.

Keywords: NFKBIA; Nasopharyngeal carcinoma; Single nucleotide polymorphisms; Susceptibility.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Alleles
Asian People
Carcinogenesis / genetics
Case-Control Studies
China
Female
Genetic Predisposition to Disease
Genotype
Humans
I-kappa B Kinase / genetics
MAP Kinase Kinase 4 / genetics
Male
Middle Aged
NF-KappaB Inhibitor alpha / genetics*
Nasopharyngeal Carcinoma / ethnology
Nasopharyngeal Carcinoma / genetics*
Nasopharyngeal Neoplasms / ethnology
Nasopharyngeal Neoplasms / genetics*
Polymorphism, Single Nucleotide*
Promoter Regions, Genetic
Risk
Signal Transduction
TNF Receptor-Associated Factor 3 / genetics
Young Adult

Substances

NFKBIA protein, human
TNF Receptor-Associated Factor 3
TRAF3 protein, human
NF-KappaB Inhibitor alpha
CHUK protein, human
I-kappa B Kinase
MAP Kinase Kinase 4
MAP2K4 protein, human