Recent advances on TMDCs for medical diagnosis

Si Meng; Yuyan Zhang; Huide Wang; Lude Wang; Tiantian Kong; Han Zhang; S Meng

doi:10.1016/j.biomaterials.2020.120471

Recent advances on TMDCs for medical diagnosis

Biomaterials. 2021 Feb:269:120471. doi: 10.1016/j.biomaterials.2020.120471. Epub 2020 Oct 27.

Authors

Si Meng¹, Yuyan Zhang², Huide Wang³, Lude Wang³, Tiantian Kong⁴, Han Zhang⁵, S Meng¹

Affiliations

¹ College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China; Department of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, 518000, China.
² College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, 518000, China.
³ College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
⁴ Department of Biomedical Engineering, School of Medicine, Shenzhen University, Shenzhen, 518000, China. Electronic address: ttkong@szu.edu.cn.
⁵ College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China. Electronic address: hzhang@szu.edu.cn.

PMID: 33160702
DOI: 10.1016/j.biomaterials.2020.120471

Abstract

Transition metal dichalcogenides (TMDCs), such as MoS₂ and WS₂, have attracted much attention in biosensing and bioimaging due to its excellent stability, biocompatibility, high specific surface area, and wide varieties. In this review, we overviewed the application of TMDCs in biosensing and bioimaging. Firstly, the synthesis methods and surface functionalization methods of TMDCs were summarized. Secondly, according to the working mechanism, we classified and gave a detailed account of the latest research progress of TMDC-based biosensing for the detection of the enzyme, DNA, and other biological molecules. Then, we outlined the recent progress of applying TMDCs in bio-imaging, including fluorescence, X-ray computed tomographic, magnetic response imaging, photographic and multimodal imaging, respectively. Finally, we discussed the future challenges and development direction of the application of TMDCs in medical diagnosis. Also, we put forward our view on the opportunity of TMDCs in the big data of modern medical diagnosis.

Keywords: 2D crystal; Bioimaging); Biosensing; Medical diagnosis; Transition metal dichalcogenides.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

DNA*

Substances

DNA