Validation of the mobile verbal learning test: Illustration of its use for age and disease-related cognitive deficits

Int J Methods Psychiatr Res. 2021 Mar;30(1):e1859. doi: 10.1002/mpr.1859. Epub 2020 Nov 7.

Abstract

Objective: We developed a mobile cognitive test of verbal learning and memory, the mobile verbal learning test (mVLT), to allow for brief, repeated and portable delivery of a 12-item list learning test through a smartphone. This study examined the psychometric properties of the mVLT among older persons with and without human immunodeficiency virus (HIV).

Methods: Sixty-eight persons with HIV and 36 HIV-negative individuals (aged 50-74) completed three trials of the mVLT on a smartphone once daily for 14 days. A different word list was administered each day.

Results: Participants completed 80% of the 14 mVLT administrations, equating to 1166 valid and complete mVLTs. Neither adherence nor mean mVLT total score (number correct in 3 recall trials) differed by HIV status. No practice effects from repeated mVLT administration were observed, and there were moderately strong correlations of mVLT performance with performance on the in-lab version of the task and with traditional cognitive assessments of cognitive processes contributing to memory. We found evidence of within-person learning across mVLT trials, with persons with HIV demonstrating less learning from trials 1 to 3 compared to HIV-negative participants.

Conclusions: The mVLT is a valid method to assess learning in the real world in older adults with and without HIV.

Keywords: ambulatory assessment; ecological momentary assessment; memory; mobile health; smartphones.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cognition
  • Cognitive Dysfunction* / diagnosis
  • Cognitive Dysfunction* / etiology
  • Humans
  • Neuropsychological Tests
  • Smartphone
  • Verbal Learning*