Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

Abstract

Background: Several quinones are on the pharmaceutical market as drugs for the treatment of several diseases.

Objective: The aim of this review was to provide an overview of the quinones that have become drugs for several therapeutic applications.

Methods: We have comprehensively and critically discussed all the information available in the literature about quinone-based drugs.

Results: In this review, the various aspects of the chemistry and biochemistry of these drugs are highlighted, including their repositioning, drug combination and their new uses.

Conclusion: A number of studies related to quinone drugs for different pharmaceutical uses show that the interest in new applications is still increasing in recent years.

Keywords: Atovaquone; buparvaquone; doxorubicin; mitomycins; mitoxantrone.; parvaquone; valrubicin.