Toxicological alert: Exposure to glycidyl methacrylate and cancer risk

Toxicol Ind Health. 2020 Dec;36(12):937-939. doi: 10.1177/0748233720957816. Epub 2020 Nov 6.

Abstract

Glycidyl methacrylate (GMA; CAS no. 106-91-2) is a chemical monomer used in the manufacture of dental resins, can coatings and polymers. GMA has demonstrated toxicity to the ocular, digestive, respiratory and dermal systems. Human exposure occurs mainly in the workplace, but it can also happen through food. Although there were no available data on carcinogenicity of GMA, carcinogenic potential in the nasal cavity is highly expected. Further studies are needed to assess GMA exposure in humans. This study provides an alert of GMA human exposure and its genotoxic and carcinogenic potential.

Keywords: GMA exposure; Glycidyl methacrylate (CAS no. 106-91-2); carcinogenicity; genotoxicity; occupational health.

Publication types

  • Letter

MeSH terms

  • DNA Damage
  • Epoxy Compounds / toxicity*
  • Humans
  • Methacrylates / toxicity*
  • Occupational Diseases / chemically induced*
  • Occupational Exposure / adverse effects

Substances

  • Epoxy Compounds
  • Methacrylates
  • glycidyl methacrylate