A self-accelerated biocatalyst for glucose-initiated tumor starvation and chemodynamic therapy

Abstract

A self-accelerated biocatalyst (Bio-Cat) was developed based on BSA and GOx crosslinked nanoproteins for glucose-initiated tumor starvation and chemodynamic therapy. Bio-Cat could catalyze the glucose to elevate the intracellular H₂O₂ level and accelerate the conversion of Fe³⁺/Fe²⁺, resulting in an effective starvation therapy and an accelerated Fenton reaction for chemodynamic therapy.