The OGTT is highly reproducible in Africans for the diagnosis of diabetes: Implications for treatment and protocol design

Ram Jagannathan; Christopher W DuBose; Lilian S Mabundo; Stephanie T Chung; Joon Ha; Arthur Sherman; Michael Bergman; Anne E Sumner

doi:10.1016/j.diabres.2020.108523

The OGTT is highly reproducible in Africans for the diagnosis of diabetes: Implications for treatment and protocol design

Diabetes Res Clin Pract. 2020 Dec:170:108523. doi: 10.1016/j.diabres.2020.108523. Epub 2020 Oct 22.

Authors

Ram Jagannathan¹, Christopher W DuBose², Lilian S Mabundo², Stephanie T Chung², Joon Ha³, Arthur Sherman³, Michael Bergman⁴, Anne E Sumner⁵

Affiliations

¹ Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States.
² Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, United States.
³ Laboratory of Biological Modeling, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.
⁴ Division of Endocrinology and Metabolism, Department of Medicine and of Population Health, New York University School of Medicine, New York, NY, United States.
⁵ Section on Ethnicity and Health, Diabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, United States; National Institute of Minority Health and Health Disparities, National Institutes of Health, Bethesda, MD, United States. Electronic address: annes@mail.nih.gov.

Abstract

Whether an OGTT reproducibly detects either type 2 diabetes (T2D) or prediabetes in Africans in unknown. Therefore, 131 Africans had two OGTT. Diagnostic reproducibility for T2D was excellent (κ = 0.84), but only moderate for prediabetes (κ = 0.51). A single OGTT positive for T2D may be sufficient to guide clinical care and inform epidemiologic study design. ClinicalTrials.gov Identifier: NCT00001853.

Keywords: Africans; Diabetes; Fasting plasma glucose; OGTT.

MeSH terms

Adult
Africa
Aged
Blood Glucose / metabolism*
Diabetes Mellitus, Type 2 / diagnosis*
Female
Glucose Tolerance Test / methods*
Humans
Male
Middle Aged
Reproducibility of Results
Young Adult

Substances

Blood Glucose

Associated data

ClinicalTrials.gov/NCT00001853