Phthalate Exposure, Adolescent Health, and the Need for Primary Prevention

Endocrinol Metab Clin North Am. 2020 Dec;49(4):759-770. doi: 10.1016/j.ecl.2020.08.004. Epub 2020 Oct 14.

Abstract

Phthalates, a class of endocrine-disrupting chemicals, are used widely in many consumer products, and exposure can interfere with a range of hormonal functions during early life. These disruptions may alter development during late childhood and adolescence. This article discusses the potential effects of phthalate exposure on adiposity, puberty, and neurodevelopment during late childhood and adolescence. It also highlights studies of behavioral interventions to reduce phthalate exposures and the roles of health care professionals and policy makers in preventing phthalate exposure.

Keywords: Adolescent health; Endocrine-disrupting chemicals; Neurodevelopment; Obesity; Phthalates; Puberty.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Adolescent Development* / drug effects
  • Adolescent Health*
  • Endocrine Disruptors / adverse effects*
  • Environmental Exposure* / adverse effects
  • Environmental Exposure* / prevention & control
  • Female
  • Humans
  • Pediatric Obesity* / chemically induced
  • Phthalic Acids / adverse effects*
  • Pregnancy
  • Prenatal Exposure Delayed Effects* / prevention & control
  • Primary Prevention*
  • Puberty* / drug effects

Substances

  • Endocrine Disruptors
  • Phthalic Acids
  • phthalic acid