Genetic variant rs72613567 of HSD17B13 gene reduces alcohol-related liver disease risk in Chinese Han population

Haizhen Chen; Yanfang Zhang; Tongsheng Guo; Funing Yang; Yuanli Mao; Liubing Li; Chenxi Liu; Haidi Gao; Yuting Jin; Yuanyuan Che; Yongzhe Li; Jing Huang

doi:10.1111/liv.14616

Genetic variant rs72613567 of HSD17B13 gene reduces alcohol-related liver disease risk in Chinese Han population

Liver Int. 2020 Sep;40(9):2194-2202. doi: 10.1111/liv.14616. Epub 2020 Aug 3.

Authors

Haizhen Chen^{1

2}, Yanfang Zhang^{1

2}, Tongsheng Guo^{3

4}, Funing Yang⁵, Yuanli Mao⁴, Liubing Li², Chenxi Liu², Haidi Gao¹, Yuting Jin¹, Yuanyuan Che¹, Yongzhe Li², Jing Huang¹

Affiliations

¹ Department of Clinical Laboratory, The First Hospital of Jilin University, Jilin, China.
² Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
³ Department of Clinical Laboratory, Beijing Mentougou District Hospital, Beijing, China.
⁴ Department of Center of Clinical Laboratory Medicine, The Fifth Medical Center of the General Hospital of the Chinese People's Liberation Army, Beijing, China.
⁵ Department of Pediatrics Outpatient Service, The First Hospital of Jilin University, Jilin, China.

Abstract

Background & aims: Recently, the variant rs72613567:TA in the 17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) has been associated with reduced levels of ALT and AST and a reduced risk of alcohol-related liver disease (ALD) in the European population. Therefore, the aim of this study was to investigate the association between the polymorphisms of HSD17B13 and ALD, liver serum markers and patatin-like phospholipase domain-containing protein 3 (PNPLA3) p.I148M in the Chinese Han population.

Methods: A case-control study was performed from five centres and included 769 ALD patients and 767 healthy controls. Two SNPs (rs72613567 and rs6834314) in HSD17B13 were genotyped using the Sequenom MassArray system and allele association analysis was performed using PLINK 1.90 software.

Results: HSD17B13 rs72613567:TA allele was associated with a reduced risk of ALD by 19% (95% confidence interval [CI]: 0.05-0.31, P = .01), uniformly, the G allele in the rs6834314 reduced the risk of ALD by 19% (95% CI: 0.05-0.31, P = 8.28 × 10^-3). And the genotypes of two SNPs were associated with reducing the risk of ALD in three genetic model analysis. In addition, we found that TA allele was associated with lower levels of serum ALT, AST and GGT (P = .005, .007 and .02, respectively), higher level of serum ALB (P = .02), but not associated with ALP. In this cohort, the interaction between HSD17B13 rs72613567 and the steatogenic allele PNPLA3 rs738409 was not validated.

Conclusion: The present study revealed that HSD17B13 rs72613567 was significantly associated with a reduced risk of ALD in Chinese Han population.

Keywords: HSD17B13; alcohol‐related liver disease; single‐nucleotide polymorphism.

MeSH terms

Case-Control Studies
China
Genetic Predisposition to Disease
Humans
Liver Diseases*
Polymorphism, Single Nucleotide