A minimalistic catalytically-active cell mimetic made of a supra-molecular hydrogel encapsulated into a polymersome

Chem Commun (Camb). 2020 Nov 19;56(92):14487-14490. doi: 10.1039/d0cc04941g.

Abstract

A minimalistic multicomponent cell mimetic is described consisting of a fibrillar network formed by the self-assembly of a low molecular weight compound (cytoskeleton-like) that is entrapped into a polymersome (membrane-like), namely a jelly-polymersome. A simple imidazole-appended hydrogelator is used in order to obtain a catalytic nanoreactor able to hydrolyze an ester within the compartment in its self-assembled state.

MeSH terms

  • Biomimetic Materials / chemistry*
  • Catalysis
  • Hydrogels / chemistry*
  • Hydrogen-Ion Concentration
  • Hydrolysis
  • Imidazoles / chemistry*
  • Molecular Weight
  • Nanostructures / chemistry
  • Peptides / chemistry*
  • Polyethylene Glycols / chemistry*
  • Polyglutamic Acid / analogs & derivatives*
  • Polyglutamic Acid / chemistry
  • Protein Multimerization

Substances

  • Hydrogels
  • Imidazoles
  • Peptides
  • poly-gamma-benzyl-L-glutamate
  • Polyglutamic Acid
  • Polyethylene Glycols
  • imidazole