6p21 translocation renal cell carcinoma: A case report

Yuho Sano; Ryuta Tanimoto; Katsumi Sasaki; Satoko Nakamura; Koichi Mizobuchi; Naoto Kuroda

doi:10.1016/j.eucr.2020.101470

6p21 translocation renal cell carcinoma: A case report

Urol Case Rep. 2020 Oct 24:34:101470. doi: 10.1016/j.eucr.2020.101470. eCollection 2021 Jan.

Authors

Yuho Sano¹, Ryuta Tanimoto¹, Katsumi Sasaki¹, Satoko Nakamura², Koichi Mizobuchi², Naoto Kuroda³

Affiliations

¹ Department of Urology, Kagawa Prefectural Central Hospital, Japan.
² Department of Pathology, Kagawa Prefectural Central Hospital, Japan.
³ Department of Pathology, Konan Medical Center, USA.

Abstract

6p21 translocation renal cell carcinoma (RCC) was newly classified in the WHO 2016 classification as a subtype of microphthalmia-associated transcription factor (MIT) family translocation RCC.A 42-year-old man was referred to our hospital with an asymptomatic solid mass in the right kidney identified during routine medical checkup. Computed tomography (CT) revealed a 14-mm buried-type solid mass accompanied by punctate calcification. CT-guided biopsy suggested clear-cell carcinoma. He underwent robotic-assisted partial nephrectomy. Pathological findings revealed 6p21 translocation RCC based on diffuse nuclear immunoreactivity for TFEB and TFEB gene rearrangement in tumor cells by FISH analysis.

Keywords: 6p21 translocation RCC; MIT family Translocation; Robotic-assisted partial nephrectomy; TFEB.

Publication types

Case Reports