Arterial oxygen pressure targets in critically ill patients: Analysis of a large ICU database

Abstract

Background: Providing supplemental oxygen is common in the management of critically ill patients, yet the optimal oxygen regimen remains unclear.

Objectives: To explore the optimal range of PaO₂ in critically ill patients.

Methods: This is a retrospective study conducted in the Medical Information Mart for Intensive Care III (MIMIC-III) database. The patients with a least 48 h of oxygen therapy were included. Nonlinear regression was used to analyze the association between PaO₂ and mortality. We derived an optimal range of PaO₂ and evaluated the association between the proportion of PaO₂ measurements within this range and mortality.

Results: In total, 8401 patients were included in the study. A J-shaped relationship was observed between median PaO₂ and hospital mortality. Compared with the reference group of 100-120 mmHg, patients with values of 80-100 mmHg and 120-140 mmHg had higher hospital mortality (adjusted odds ratio [aOR], 1.23; 95% CI, 1.05-1.43 and 1.29; 95%CI, 1.08-1.54, respectively). Similarly, mortality rates were significantly higher for PaO₂ <80 mmHg and ≥140 mmHg (aOR, 1.97; 95%CI, 1.58-2.45 and 1.42; 95%CI, 1.19-1.69, respectively). Patients spent a greater proportion of time within 100-120 mmHg tended to have a lower mortality rate.

Conclusion: Among critically ill patients, the relationship between median PaO₂ and hospital mortality was J-shaped. The lowest rates of mortality was observed in those with PaO₂ levels within 100 to 120 mmHg.

Keywords: Arterial oxygenation; Hospital mortality; Intensive care units; Optimal range; Oxygen therapy.