The Relative Impact of Urinary and Sexual Function vs Bother on Health Utility for Men With Prostate Cancer

Chang Wook Jeong; Annika Herlemann; Janet E Cowan; Jeanette M Broering; Renske M T Ten Ham; Leslie S Wilson; Peter R Carroll; Matthew R Cooperberg

doi:10.1093/jncics/pkaa044

The Relative Impact of Urinary and Sexual Function vs Bother on Health Utility for Men With Prostate Cancer

JNCI Cancer Spectr. 2020 May 25;4(5):pkaa044. doi: 10.1093/jncics/pkaa044. eCollection 2020 Oct.

Authors

Chang Wook Jeong^{1

2}, Annika Herlemann^{1

3}, Janet E Cowan¹, Jeanette M Broering¹, Renske M T Ten Ham^{4

5}, Leslie S Wilson⁴, Peter R Carroll¹, Matthew R Cooperberg^{1

6}

Affiliations

¹ Diller Family Comprehensive Cancer Center, Department of Urology, University of California, San Francisco, CA, USA.
² Department of Urology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea.
³ Department of Urology, Ludwig-Maximilians-University of Munich, Munich, Germany.
⁴ Health Policy and Economics, Department of Clinical Pharmacy, University of California, San Francisco, CA, USA.
⁵ Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.
⁶ Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.

Abstract

Function and bother are related but distinct aspects of health-related quality of life. The objective of this study was to compare quantitatively the relative impacts of function and bother in urinary, sexual, and bowel outcomes on health utility as a reflection of health-related quality of life in men with prostate cancer. Our analysis included participants in the Cancer of the Prostate Strategic Urologic Research Endeavor utility supplementary study, with a final cohort of 1617 men. Linear regression on the patients' function and bother summary scores (0-100) from the University of California, Los Angeles Prostate Cancer Index was performed to predict bias-corrected health utilities. Urinary and sexual bother were associated with each health utility, and their coefficients were 3.7 and 20.8 times greater, respectively, than those of the corresponding function. To our knowledge, our study provides the first quantitative and direct comparison of the impacts of function vs bother on health utility.