Individuals can differ in how their behavioral and physiological systems are organized. The fact that these individual differences persist across life suggests they are supported by physical structures that may co-vary. Here, we explored three datasets associated with health and behavioral outcomes, which were obtained from infant rhesus monkeys during standardized assessment of biobehavioral organization. Variation in biobehavioral measures was related to variation in molecular pathways, as assessed by metabolomics. Plasma from infant male rhesus monkeys ( Macaca mulatta) ( n=52) was subjected to metabolite profiling. Principal component analyses identified multiple factors that explained 60%-80% of the variance in the metabolite measures. Correlational and regression analyses of corticosteroid, hematological, and temperament measures revealed significant relationships with indicators of lipid metabolism. Significant relationships were found for cortisol responses to stress and adrenocorticotropin (ACTH) stimulation, indicators of innate immunity (monocytes and natural killer (NK) cells), hemoglobin/hematocrit, and three measures of temperament. It will be important to replicate this first-of-a-kind study to determine whether the relationship between measures of biobehavioral organization and lipid metabolism are a general result, or one that is specific to early development.
动物因其行为和生理的组织方式不同而存在个体差异，这种差异可持续一生，伴随动物身体结构的共同变化可能导致该差异的产生。本文研究了三组与健康和行为相关的幼年恒河猴的标准生物行为学数据集。代谢组学分析结果显示，恒河猴的生物行为学差异与分子通路差异相关。对幼年雄性恒河猴(n=52)的血浆进行代谢物分析，主成分分析确定了可解释代谢物测量60%-80%差异的多种因素。对皮质醇（可的松）、血液学和动物个性特质的相关性回归分析显示它们与脂类代谢显著相关。皮质醇对应激和促肾上腺皮质激素（ACTH）刺激的反应、固有免疫指标（单核细胞和自然杀伤细胞（NK）细胞）、血红蛋白/红细胞压积与三种个性特质之间存在显著相关性。重复检验这一首次发现非常重要，将有助于我们揭示生物行为学和脂类代谢的相关性是否为普遍性结果，或只是存在于动物早期发育的一个特定现象。.
Keywords: Corticosteroid (Cortisol); Hematology; Lipid metabolism; Rhesus monkey; Temperament.