Guidelines for establishing a 3-D printing biofabrication laboratory

Henry W Sanicola; Caleb E Stewart; Michael Mueller; Farzad Ahmadi; Dadong Wang; Sean K Powell; Korak Sarkar; Kenneth Cutbush; Maria A Woodruff; David A Brafman

doi:10.1016/j.biotechadv.2020.107652

Guidelines for establishing a 3-D printing biofabrication laboratory

Biotechnol Adv. 2020 Dec:45:107652. doi: 10.1016/j.biotechadv.2020.107652. Epub 2020 Oct 27.

Authors

Affiliations

¹ Faculty of Medicine, The University of Queensland, Brisbane 4006, Australia.
² Department of Neurosurgery, Louisiana State Health Sciences Center, Shreveport, LA 71103, USA. Electronic address: caleb.stewart@uq.net.au.
³ CSIRO Manufacturing, Clayton, Victoria 3169, Australia.
⁴ Department of Electrical and Computer Engineering, Youngstown State University, Youngstown, OH 44555, USA.
⁵ Quantitative Imaging Research Team, Data61, Commonwealth Scientific and Industrial Research Organization, Marsfield, NSW 2122, Australia.
⁶ Science and Engineering Faculty, Queensland University of Technology, Brisbane 4029, Australia.
⁷ M3D Laboratory, Ochsner Health System, New Orleans, LA 70121, USA.
⁸ Science and Engineering Faculty, Queensland University of Technology, Brisbane 4029, Australia. Electronic address: mia.woodruff@qut.edu.au.
⁹ School of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA. Electronic address: david.brafman@asu.edu.

PMID: 33122013
DOI: 10.1016/j.biotechadv.2020.107652

Abstract

Advanced manufacturing and 3D printing are transformative technologies currently undergoing rapid adoption in healthcare, a traditionally non-manufacturing sector. Recent development in this field, largely enabled by merging different disciplines, has led to important clinical applications from anatomical models to regenerative bioscaffolding and devices. Although much research to-date has focussed on materials, designs, processes, and products, little attention has been given to the design and requirements of facilities for enabling clinically relevant biofabrication solutions. These facilities are critical to overcoming the major hurdles to clinical translation, including solving important issues such as reproducibility, quality control, regulations, and commercialization. To improve process uniformity and ensure consistent development and production, large-scale manufacturing of engineered tissues and organs will require standardized facilities, equipment, qualification processes, automation, and information systems. This review presents current and forward-thinking guidelines to help design biofabrication laboratories engaged in engineering model and tissue constructs for therapeutic and non-therapeutic applications.

Keywords: Biofabrication; Bioprinting; Cloud manufacturing; Deep learning; Tissue engineering.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Bioprinting*
Laboratories*
Printing, Three-Dimensional
Reproducibility of Results
Tissue Engineering