Langerhans cells (LCs) are immune cells that reside in the stratified epithelium of the skin and mucosal membranes. They play a range of roles in the skin, including antigen presentation and maintenance of peripheral tolerance. Reports of LC numbers have been variable in different cancer types, with the majority of studies indicating a reduction in their number. Changes in the cytokine profile and other secreted molecules, downregulation of surface molecules on cells and hypoxia all contribute to the regulation of LCs in the tumour microenvironment. Functionally, LCs have been reported to regulate immunity and carcinogenesis in different cancer types. An improved understanding of the function and biology of LCs in tumours is essential knowledge that underpins the development of new cancer immunotherapies.
Keywords: Angiogenesis; Antigen presentation; Cancer; Carcinogenesis; Cytokines; Human; Hypoxia; Immune cells; Immunity; Immunotherapy; Langerhans cell; Lymphangiogenesis; Mice; Surface molecules; Tumour microenvironment.