Vessel Size Imaging is Associated with IDH Mutation and Patient Survival in Diffuse Lower-Grade Glioma

Houyi Kang; Peng Chen; Hong Guo; Letian Zhang; Yong Tan; Hualiang Xiao; Ao Yang; Jingqin Fang; Weiguo Zhang

doi:10.2147/CMAR.S266533

Vessel Size Imaging is Associated with IDH Mutation and Patient Survival in Diffuse Lower-Grade Glioma

Cancer Manag Res. 2020 Oct 8:12:9801-9811. doi: 10.2147/CMAR.S266533. eCollection 2020.

Authors

Houyi Kang^#^{1

2}, Peng Chen^#^{1

2}, Hong Guo^{1

2}, Letian Zhang^{1

2}, Yong Tan^{1

2}, Hualiang Xiao³, Ao Yang⁴, Jingqin Fang^{1

2}, Weiguo Zhang^{1

2}

Affiliations

¹ Department of Radiology, Daping Hospital, Army Medical University, Chongqing 400042, People's Republic of China.
² Chongqing Clinical Research Center of Imaging and Nuclear Medicine, Chongqing, People's Republic of China.
³ Department of Pathology, Daping Hospital, Army Medical University, Chongqing, People's Republic of China.
⁴ Department of Traffic Injury Research Office, Daping Hospital, Army Medical Center of PLA, Chongqing, People's Republic of China.

^# Contributed equally.

Abstract

Background: Patients with isocitrate dehydrogenase (IDH) mutant gliomas have better survival and appear to be more sensitive to chemotherapy than their IDH wild-type counterparts. We attempted to assess the correlations of vessel size imaging (VSI) values with IDH mutation status and patient survival in diffuse lower-grade glioma (LGG).

Methods: We enrolled 60 patients with diffuse LGGs, among which 43 had IDH-mutant tumors. All patients underwent VSI examination and VSI values for active tumors were calculated. Receiver operating characteristic (ROC) curves were established to evaluate the detection efficiency. Logistic regression was employed to determine the ability of variables to discriminate IDH mutational status. Kaplan-Meier survival analysis and Cox proportional hazards models were utilized to estimate the correlations of VSI values and other risk factors with patient survival.

Results: We observed that VSI values were lower in IDH-mutant LGGs than IDH wild-type LGGs. The VSImax and VSImean values had AUC values of 0.7305 and 0.7401, respectively, in distinguishing IDH-mutant LGGs from IDH wild-type LGGs. Logistic regression showed that VSImean values, age and tumor location were associated with IDH-mutant status, and the formula integrating the three factors had an AUC value of 0.7798 when distinguishing IDH-mutant LGGs from IDH wild-type LGGs. Moreover, LGG patients with high VSI values exhibited worse survival rates than those with low VSI values for both progression-free survival (PFS) and overall survival (OS). Multivariate Cox proportional hazards regression analysis suggested that IDH mutation status, VSImean values and multiple lesions or lobes were risk factors for PFS of LGG patients.

Conclusion: VSI value is associated with IDH genotype and maybe an independent predictor of the survival of patients with LGGs.

Keywords: IDH; glioma; isocitrate dehydrogenase; mutation; survival; vessel size imaging.

Grants and funding

The present study was supporting by the Chongqing Health Commission Fund (grant no. 2018QNXM026) and National Natural Science Foundation of China (grant no. 81871421) and National Key Research and Development Program of China (grant no. 2018YFC0115004).