Kidney transplantation from living donor with monolateral renal artery fibromuscular dysplasia using a cryopreserved iliac graft for arterial reconstruction: a case report and review of the literature

BMC Nephrol. 2020 Oct 28;21(1):451. doi: 10.1186/s12882-020-02097-w.

Abstract

Background: Aging and mortality of patients on waiting lists for kidney transplantation have increased, as a result of the shortage of organs available all over the world. Living donor grafts represent a significant source to maintain the donor pool, and resorting successfully to allografts with arterial disease has become a necessity. The incidence of renal artery fibromuscular dysplasia (FMD) in potential living renal donors is reported to be 2-6%, and up to 4% of them present concurrent extra-renal involvement.

Case presentation: We present a case of renal transplantation using a kidney from a living donor with monolateral FMD. Resection of the affected arterial segment and its subsequent replacement with a cryopreserved iliac artery graft from a deceased donor were performed. No intraoperative nor post-operative complications were reported. The allograft function promptly resumed, with satisfying creatinine clearance, and adequate patency of the vascular anastomoses was detected by Doppler ultrasounds.

Conclusion: Literature lacks clear guidelines on the eligibility of potential living renal donors with asymptomatic FMD. Preliminary assessment of the FMD living donor should always rule out any extra-renal involvement. Whenever possible, resection and reconstruction of the affected arterial segment should be taken into consideration as this condition may progress after implantation.

Keywords: Arterial reconstruction; Cryopreserved cadaveric iliac graft; Fibromuscular dysplasia; Living donor; Renal transplant.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Asymptomatic Diseases
  • Blood Urea Nitrogen
  • Cadaver
  • Creatinine / blood
  • Cryopreservation
  • Fibromuscular Dysplasia / complications*
  • Glomerular Filtration Rate
  • Humans
  • Iliac Artery / physiology
  • Iliac Artery / transplantation*
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / surgery*
  • Kidney Transplantation / methods*
  • Living Donors*
  • Male
  • Renal Artery* / physiology
  • Renal Veins / physiology
  • Transplantation, Homologous
  • Vascular Patency

Substances

  • Creatinine