Applications of NMR in Drug:Cyclodextrin Complexes

Dimitrios Ntountaniotis; Georgios Leonis; Eirini Christodoulou; Thomas Mavromoustakos

doi:10.1007/978-1-0716-0920-0_22

Applications of NMR in Drug:Cyclodextrin Complexes

Methods Mol Biol. 2021:2207:313-325. doi: 10.1007/978-1-0716-0920-0_22.

Authors

Dimitrios Ntountaniotis¹, Georgios Leonis², Eirini Christodoulou², Thomas Mavromoustakos²

Affiliations

¹ Chemistry Department, Laboratory of Organic Chemistry, National Kapodistrian University of Athens, Athens, Greece. doudaniotis@yahoo.gr.
² Chemistry Department, Laboratory of Organic Chemistry, National Kapodistrian University of Athens, Athens, Greece.

PMID: 33113144
DOI: 10.1007/978-1-0716-0920-0_22

Abstract

NMR spectroscopy is an effective technique, applicable for studying bioactive materials or drug delivery systems in order to obtain comprehensive details related to structural and dynamic characteristics at atomic resolution. The applications of NMR spectroscopy have been increased considerably as a result of the combination of advancement in technological NMR instrumentation and scientific knowledge. This chapter is dedicated to highlight the applications of NMR spectroscopy in drug:cyclodextrin complexes using both liquid- and solid-state NMR spectroscopy.

Keywords: Cyclodextrins; Drug delivery systems; NMR spectroscopy for liquids and solids; Nuclear magnetic resonance; Structural properties.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cyclodextrins / chemistry*
Drug Delivery Systems*
Nuclear Magnetic Resonance, Biomolecular*
Pharmaceutical Preparations / chemistry*

Substances

Cyclodextrins
Pharmaceutical Preparations