Sudden cardiac death in children with congenital heart disease: a critical review of the literature

Cardiol Young. 2020 Nov;30(11):1559-1565. doi: 10.1017/S1047951120003613. Epub 2020 Oct 28.

Abstract

Sudden cardiac death is an uncommon but yet catastrophic event, which can occur in neonates and young children. Although extensive research has been carried out assessing the underlying causes, there still remains a degree of uncertainty around this area. Congenital heart disease (CHD) is one known cause of sudden cardiac death in children, the aetiology of which embraces virally induced mechanisms, genetic susceptibility, drug-induced, and maternal factors. Screening tools and investigations including electrocardiograms and echocardiograms alongside a concise history taking and physical examination can be used to identify the potential cardiovascular risk factors of sudden death. This review has comprehensively studied the causes and risk factors for sudden cardiac death in children with CHD and provides a collation and summary of the evidence available so far underpinning the complex link between the two. Moreover, current screening and prevention methods are discussed in detail in order to increase awareness and understanding of how we can improve patient outcomes.

Keywords: Arrest; anomaly; death; failure; heart.

Publication types

  • Review

MeSH terms

  • Child
  • Child, Preschool
  • Death, Sudden, Cardiac* / epidemiology
  • Death, Sudden, Cardiac* / etiology
  • Echocardiography
  • Electrocardiography
  • Heart Defects, Congenital* / complications
  • Humans
  • Infant, Newborn
  • Risk Factors