The Role of HDACs and HDACi in Cartilage and Osteoarthritis

He Zhang; Lu Ji; Yue Yang; Xiaoning Zhang; Yi Gang; Lunhao Bai

doi:10.3389/fcell.2020.560117

The Role of HDACs and HDACi in Cartilage and Osteoarthritis

Front Cell Dev Biol. 2020 Sep 30:8:560117. doi: 10.3389/fcell.2020.560117. eCollection 2020.

Authors

He Zhang¹, Lu Ji², Yue Yang¹, Xiaoning Zhang³, Yi Gang⁴, Lunhao Bai¹

Affiliations

¹ Department of Orthopedic Surgery, Shengjing Hospital, China Medical University, Shenyang, China.
² Department of Gynecology and Obstetrics, Shengjing Hospital, China Medical University, Shenyang, China.
³ Department of Anesthesiology, Shengjing Hospital, China Medical University, Shenyang, China.
⁴ Department of Orthopedic Surgery, Panjin Central Hospital, Panjin, China.

Abstract

Epigenetics plays an important role in the pathogenesis and treatment of osteoarthritis (OA). In recent decades, HDAC family members have been associated with OA. This paper aims to describe the different role of HDACs in the pathogenesis of OA through interaction with microRNAs and the regulation of relevant signaling pathways. We found that HDACs are involved in cartilage and chondrocyte development but also play a crucial role in OA. However, the distinct HDAC mechanism in the pathogenesis and treatment of OA require further investigation. Furthermore, HDAC inhibitors (HDACi) can protect cartilage from disease, which may represent a potential therapeutic approach against OA.

Keywords: HDAC; HDAC inhibitor; cartilage; microRNA; osteoarthritis.

Publication types

Review