A systematic review of post-translational modifications in the mitochondrial permeability transition pore complex associated with cardiac diseases

Abstract

The mitochondrial permeability transition pore (mPTP) opening is involved in the pathophysiology of multiple cardiac diseases, such as ischemia/reperfusion injury and heart failure. A growing number of evidence provided by proteomic screening techniques has demonstrated the role of post-translational modifications (PTMs) in several key components of the pore in response to changes in the extra/intracellular environment and bioenergetic demand. This could lead to a fine, complex regulatory mechanism that, under pathological conditions, can shift the state of mitochondrial functions and, thus, the cell's fate. Understanding the complex relationship between these PTMs is still under investigation and can provide new, promising therapeutic targets and treatment approaches. This review, using a systematic review of the literature, presents the current knowledge on PTMs of the mPTP and their role in health and cardiac disease.

Keywords: Cardiac disease; Cardiac physiology; Cardiac physiopathology; Diabetic cardiomyopathy; Heart failure; Ischemia/reperfusion injury; Mitochondrial permeability transition pore; Obesity cardiomyopathy; Post-translational modifications; Systematic review.