Gorlin-Goltz syndrome and epilepsy: A two-case report and review of the literature

Daniel Tomasso; Elie Bou Assi; Dang Khoa Nguyen

doi:10.1016/j.ebr.2020.100384

Gorlin-Goltz syndrome and epilepsy: A two-case report and review of the literature

Epilepsy Behav Rep. 2020 Aug 7:14:100384. doi: 10.1016/j.ebr.2020.100384. eCollection 2020.

Authors

Daniel Tomasso¹, Elie Bou Assi¹, Dang Khoa Nguyen¹

Affiliation

¹ Department of Neurosciences, University of Montreal Hospital Research Centre, 900 St-Denis Street, Montreal, Quebec H2X 0A9, Canada.

Abstract

Gorlin-Goltz syndrome, also known as nevoid basal cell carcinoma syndrome, is a genetic disorder with several neurological, cutaneous and skeletal manifestations. Epilepsy has been previously reported as a finding in Gorlin-Goltz syndrome but remains ill-described in the context of this disease. We report two new patients with Gorlin-Goltz syndrome featuring epilepsy and review the existing literature on the topic.

Keywords: ACTH, adrenocorticotropic hormone; ATL, anterior temporal lobectomy; BTC, bilateral tonic–clonic; Basal cell carcinoma; BiF, bifrontal; BiFT, bifrontotemporal; BiT, bitemporal; CBZ, carbamazepine; CLB, clobazam; Epilepsy; F, frontal; GTC, generalized tonic–clonic; Gorlin–Goltz; HS, hippocampal sclerosis; LCM, lacosamide; LEV, levetiracetam; MR, mental retardation; P, parietal; PHT, phenytoin; Pb, phenobarbital; SHH, Sonic Hedgehog; Sonic hedgehog; T, temporal; VPA, valproic acid.

Publication types

Case Reports