Engineering a Model to Study Viral Infections: Bioprinting, Microfluidics, and Organoids to Defeat Coronavirus Disease 2019 (COVID-19)

Anastasia Shpichka; Polina Bikmulina; Maria Peshkova; Nastasia Kosheleva; Irina Zurina; Ensieh Zahmatkesh; Niloofar Khoshdel-Rad; Marina Lipina; Elena Golubeva; Denis Butnaru; Andrei Svistunov; Massoud Vosough; Peter Timashev

doi:10.18063/ijb.v6i4.302

Engineering a Model to Study Viral Infections: Bioprinting, Microfluidics, and Organoids to Defeat Coronavirus Disease 2019 (COVID-19)

Int J Bioprint. 2020 Aug 28;6(4):302. doi: 10.18063/ijb.v6i4.302. eCollection 2020.

Authors

Anastasia Shpichka^{1

2}, Polina Bikmulina¹, Maria Peshkova¹, Nastasia Kosheleva^{3

4}, Irina Zurina^{1

3}, Ensieh Zahmatkesh^{5

6}, Niloofar Khoshdel-Rad^{5

6}, Marina Lipina⁷, Elena Golubeva², Denis Butnaru⁸, Andrei Svistunov⁸, Massoud Vosough^{5

6}, Peter Timashev^{1

2

9}

Affiliations

¹ Department of Advanced Biomaterials, Institute for Regenerative Medicine, Sechenov University, Moscow, Russia.
² Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.
³ Department of Molecular and Cell Pathophysiology, FSBSI Institute of General Pathology and Pathophysiology, Moscow, Russia.
⁴ Department of Embryology, Lomonosov Moscow State University, Faculty of Biology, Moscow, Russia.
⁵ Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
⁶ Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
⁷ Department of Traumatology, Orthopedics and Disaster Surgery, Sechenov University, Moscow, Russia.
⁸ Rector's Office, Sechenov University, Moscow, Russia.
⁹ Department of Polymers and Composites, NN Semenov Institute of Chemical Physics, Moscow, Russia.

Abstract

While the number of studies related to severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) is constantly growing, it is essential to provide a framework of modeling viral infections. Therefore, this review aims to describe the background presented by earlier used models for viral studies and an approach to design an "ideal" tissue model for SARS-CoV-2 infection. Due to the previous successful achievements in antiviral research and tissue engineering, combining the emerging techniques such as bioprinting, microfluidics, and organoid formation are considered to be one of the best approaches to form in vitro tissue models. The fabrication of an integrated multi-tissue bioprinted platform tailored for SARS-CoV-2 infection can be a great breakthrough that can help defeat coronavirus disease in 2019.

Keywords: Bioprinting; Body-on-a-chip; Coronavirus; Coronavirus disease 2019; Organoids; Severe acute respiratory syndrome-related coronavirus 2; Tissue models; Viral infection; microfluidics.

Publication types

Review