DNA mismatch repair-dependent DNA damage responses and cancer

Robbert Ijsselsteijn; Jacob G Jansen; Niels de Wind

doi:10.1016/j.dnarep.2020.102923

DNA mismatch repair-dependent DNA damage responses and cancer

DNA Repair (Amst). 2020 Sep:93:102923. doi: 10.1016/j.dnarep.2020.102923.

Authors

Robbert Ijsselsteijn¹, Jacob G Jansen¹, Niels de Wind²

Affiliations

¹ Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands.
² Department of Human Genetics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, the Netherlands. Electronic address: N.de_wind@lumc.nl.

PMID: 33087264
DOI: 10.1016/j.dnarep.2020.102923

Abstract

Canonical DNA mismatch repair (MMR) excises base-base mismatches to increase the fidelity of DNA replication. Thus, loss of MMR leads to increased spontaneous mutagenesis. MMR genes also are involved in the suppression of mutagenic, and the induction of protective, responses to various types of DNA damage. In this review we describe these non-canonical roles of MMR at different lesion types. Loss of non-canonical MMR gene functions may have important ramifications for the prevention, development and treatment of colorectal cancer associated with inherited MMR gene defects in Lynch syndrome. This graphical review pays tribute to Samuel H. Wilson. Sam not only made seminal contributions to understanding base excision repair, particularly with respect to structure-function relationships in DNA polymerase β but also, as Editor of DNA Repair, has maintained a high standard of the journal.

Keywords: Colorectal cancer; DNA damage responses; DNA mismatch repair; Mutagenesis.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Colorectal Neoplasms / genetics*
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA / metabolism
DNA Damage*
DNA Mismatch Repair*
DNA Replication
Humans
Mutagenesis

Substances

DNA