Role of microRNAs in the crosstalk between osteosarcoma cells and the tumour microenvironment

Yong Lei; Chen Junxin; Huang Yongcan; Liu Xiaoguang; Yu Binsheng

doi:10.1016/j.jbo.2020.100322

Role of microRNAs in the crosstalk between osteosarcoma cells and the tumour microenvironment

J Bone Oncol. 2020 Sep 28:25:100322. doi: 10.1016/j.jbo.2020.100322. eCollection 2020 Dec.

Authors

Yong Lei^{1

2}, Chen Junxin^{1

2}, Huang Yongcan^{1

2}, Liu Xiaoguang³, Yu Binsheng¹

Affiliations

¹ Shenzhen Key Laboratory of Spine Surgery, Department of Spine Surgery, Peking University Shenzhen Hospital, Shenzhen 518036, China.
² Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen 518036, China.
³ Department of Orthopedics, Peking University Third Hospital, Beijing 100191, China.

Abstract

Osteosarcoma (OS) is the most common primary bone tumour, with a peak incidence in adolescents, and the five-year survival rate of patients with metastasis or recurrence is much lower than that of patients without metastasis and recurrence. OS is initiated and develops in a complex tumour microenvironment (TME) that contains many different components, such as osteoblasts, osteoclasts, mesenchymal stem cells, fibroblasts, immune cells, extracellular matrix (ECM), extracellular vesicles, and cytokines. The extensive interaction between OS and the TME underlies OS progression. Therefore, rather than targeting OS cells, targeting the key factors in the TME may yield novel therapeutic approaches. MicroRNAs (miRNAs) play multiple roles in the biological behaviours of OS, and recent studies have implied that miRNAs are involved in mediating the communication between OS cells and the surrounding TME. Here, we review the TME landscape and the miRNA dysregulation of OS, describe the role of the altered TME in OS development and highlight the role of miRNA in the crosstalk between OS cells and the TME.

Keywords: Osteosarcoma; Tumour microenvironment; microRNA.

Publication types

Review