Non-Coding RNAs and Hereditary Hemorrhagic Telangiectasia

Anthony Cannavicci; Qiuwang Zhang; Michael J B Kutryk

doi:10.3390/jcm9103333

Non-Coding RNAs and Hereditary Hemorrhagic Telangiectasia

J Clin Med. 2020 Oct 17;9(10):3333. doi: 10.3390/jcm9103333.

Authors

Anthony Cannavicci^{1

2}, Qiuwang Zhang², Michael J B Kutryk^{1

2}

Affiliations

¹ Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.
² Division of Cardiology, Keenan Research Center for Biomedical Sciences, St. Michael's Hospital, Unity Health Toronto, University of Toronto, Toronto, ON M5B 1T8, Canada.

Abstract

Non-coding RNAs (ncRNAs) are functional ribonucleic acid (RNA) species that include microRNAs (miRs), a class of short non-coding RNAs (∼21-25 nucleotides), and long non-coding RNAs (lncRNAs) consisting of more than 200 nucleotides. They regulate gene expression post-transcriptionally and are involved in a wide range of pathophysiological processes. Hereditary hemorrhagic telangiectasia (HHT) is a rare disorder inherited in an autosomal dominant fashion characterized by vascular dysplasia. Patients can develop life-threatening vascular malformations and experience severe hemorrhaging. Effective pharmacological therapies are limited. The study of ncRNAs in HHT is an emerging field with great promise. This review will explore the current literature on the involvement of ncRNAs in HHT as diagnostic and pathogenic factors.

Keywords: angiogenesis; biomarkers; endothelial cells; hereditary hemorrhagic telangiectasia; long non-coding RNAs; microRNAs; non-coding RNAs.

Publication types

Review

Grants and funding

U54 NS065705/NS/NINDS NIH HHS/United States