Cell Migration: Deconstructing the Matrix

Alberto Elosegui-Artola; Roger Oria

doi:10.1016/j.cub.2020.08.013

Cell Migration: Deconstructing the Matrix

Curr Biol. 2020 Oct 19;30(20):R1266-R1268. doi: 10.1016/j.cub.2020.08.013.

Authors

Alberto Elosegui-Artola¹, Roger Oria²

Affiliations

¹ Harvard John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA; Wyss Institute for Biologically Inspired Engineering, Cambridge, MA, USA; Institute for Bioengineering of Catalonia, Barcelona, Spain. Electronic address: aelosegui@seas.harvard.edu.
² Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California San Francisco, San Francisco, CA, USA. Electronic address: roger.oriafernandez@ucsf.edu.

PMID: 33080198
DOI: 10.1016/j.cub.2020.08.013

Abstract

New work identifies a mechanism of cell migration whereby cellular mechanical forces dissociate extracellular matrix (ECM) ligands from the substrate. The local dissociation of ECM ligands creates an ECM ligand gradient below the cell body that guides cellular migration.

Publication types

Comment

MeSH terms

Cell Movement
Extracellular Matrix* / metabolism
Integrins* / metabolism
Ligands
Protein Transport

Substances

Integrins
Ligands