The situation of uncertainty several people faced in Italy due to the SARS-CoV-2 epidemic suggested this contribution concerning the potential outcomes in some safety areas of the primary needs of the individual: safety and security needs, love and belonging needs, esteem, and self-actualization. When uncertainty features one or more of them, the risk of health outcomes increases, specifically with respect to mental health. This contribution compares the experience of the severe earthquake that hit Emilia-Romagna region (North Italy) in May 2012 and the epidemic of CoViD-19 officially started in Italy in February 2020. Both experiences were lived by the authors, as citizens and mental health professionals. The considerations presented stemmed out from the clinical experience and are articulated around some key words: surprise, length, places, society, work, welfare, feelings, economics. Similarities and differences are presented, suggesting that new therapeutic devices are necessary, to hold and treat patients during this specific epidemic, as well as during future ones. Up to the moment we have just been able to chase the shadow, by integrating medieval systems (quarantine) and hyper-technological systems (i.e., the most advanced resuscitation techniques).