Ratiometric ultrasensitive optical chemisensor film based antibiotic drug for Al(III) and Cu(II) detection

Reham Ali; Fahad M Alminderej; Sabri Messaoudi; Sayed M Saleh

doi:10.1016/j.talanta.2020.121412

Ratiometric ultrasensitive optical chemisensor film based antibiotic drug for Al(III) and Cu(II) detection

Talanta. 2021 Jan 1:221:121412. doi: 10.1016/j.talanta.2020.121412. Epub 2020 Jul 31.

Authors

Reham Ali¹, Fahad M Alminderej², Sabri Messaoudi³, Sayed M Saleh⁴

Affiliations

¹ Department of Chemistry, Faculty of Science, Suez University, 43518 Suez, Egypt; Department of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi Arabia.
² Department of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi Arabia.
³ Department of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi Arabia; Carthage University, Faculty of Sciences of Bizerte, 7021, Jarzouna, Tunisia.
⁴ Department of Chemistry, College of Science, Qassim University, Buraidah, 51452, Saudi Arabia; Chemistry Branch, Department of Science and Mathematics, Faculty of Petroleum and Mining Engineering, Suez University, 43721, Suez, Egypt. Electronic address: Sayed.Saleh@suezuniv.edu.eg.

PMID: 33076057
DOI: 10.1016/j.talanta.2020.121412

Abstract

Herein, we developed and designed a novel ratiometric optical chemisensor film for determining Al(III) and Cu(II) in low concentration ranges. The chemisensor film consists of (a) antibacterial drug Ciprofloxacin (CPFX) [1-cyclopropyl-6-fluoro1,4-dihydro-4-oxo-7-(piperaziny-l-yl) quinolone-3carboxylic acid] and (b) a reference dye 5,10,15,20- tetrakis (pentafluorophenyl) porphyrin (TFPP) in a polyvinyl chloride (PVC) matrix. PVC was applied as a homogeneous system for mixing CPFX and TFPP. The emission intensity of the CPFX in the PVC matrix varies depending on the concentrations of the Al(III) and Cu(II) ions. When the sensor film is immersed in different Al(III) concentrations, a significant fluorescence enhancement of the CPFX at (427 nm) is observed. Furthermore, the fluorescence intensity of the red emission of the TFPP dye at (644 nm) does not alter. However, in the presence of Cu(II) ions, a considerable emission quenching of the CPFX peak at (427 nm) is observed. PVC provides a great permeability and penetration facilities of dissolved ions that make the sensor film sensitive to Al(III) or Cu(II) changes outside the matrix. The film displays immense sensitivity depending on their distinctive optical characteristics of CPFX and detection capabilities within a low detection limit LOD for Al(III) and Cu(II). The LOD values were estimated to be 2.05 x 10^-7 M and 1.04 x 10^-7 M respectively with a relative standard deviation RSD_r (1%, n=3). Density functional theory (DFT) and the time-dependent DFT (TDDFT) theoretical calculations were performed to study Cu(II) and Al(III) complexation structures and their electronic properties in solution and in the sensor film. The interference of the chemisensor film was examined using different cations and the chemisensor provides significant selectivity. We develop a new ratiometric chemisensor based on PVC polymer film for Al(III) and Cu(II) detection.

Keywords: Al(III); Cu(II); Medical probe; Ratiometric; Sensor film; TFPP.

MeSH terms

Anti-Bacterial Agents
Ciprofloxacin
Copper*
Pharmaceutical Preparations*
Polymers

Substances

Anti-Bacterial Agents
Pharmaceutical Preparations
Polymers
Ciprofloxacin
Copper