Severe Acute Respiratory Syndrome Coronavirus 2 Attachment Receptor Angiotensin-Converting Enzyme 2 Is Decreased in Crohn's Disease and Regulated By Microbial and Inflammatory Signaling

Jay Vasant Patankar; Mircea Teodor Chiriac; Malte Lehmann; Anja A Kühl; Raja Atreya; Christoph Becker; Callaborators; Miguel Gonzalez-Acera; Heike Schmitt; Reyes Gamez-Belmonte; Mousumi Mahapatro; Leonard Diemand; Leonie Hartmann; Fabrizio Mascia; Zsuzsanna Hracsko; Veronika Thonn; Lena Schödel; Marta Zielinska; Yuqiang Yu; Lena Erkert; Wei Li; Melanie Zeitler; Barbara Ruder; Ingo Ganzleben; Claudia Günther; David Voehringer; Sebastian Zundler; Markus F Neurath; Britta Siegmund

doi:10.1053/j.gastro.2020.10.021

Severe Acute Respiratory Syndrome Coronavirus 2 Attachment Receptor Angiotensin-Converting Enzyme 2 Is Decreased in Crohn's Disease and Regulated By Microbial and Inflammatory Signaling

Gastroenterology. 2021 Feb;160(3):925-928.e4. doi: 10.1053/j.gastro.2020.10.021. Epub 2020 Oct 17.

Authors

Jay Vasant Patankar¹, Mircea Teodor Chiriac¹, Malte Lehmann², Anja A Kühl³, Raja Atreya⁴, Christoph Becker⁵; Callaborators; Miguel Gonzalez-Acera¹, Heike Schmitt¹, Reyes Gamez-Belmonte¹, Mousumi Mahapatro¹, Leonard Diemand¹, Leonie Hartmann¹, Fabrizio Mascia¹, Zsuzsanna Hracsko¹, Veronika Thonn¹, Lena Schödel¹, Marta Zielinska⁶, Yuqiang Yu¹, Lena Erkert¹, Wei Li⁷, Melanie Zeitler¹, Barbara Ruder¹, Ingo Ganzleben¹, Claudia Günther¹, David Voehringer⁸, Sebastian Zundler⁹, Markus F Neurath⁴, Britta Siegmund²

Affiliations

¹ Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany.
² Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Berlin, Germany; The Transregio 241 IBDome Consortium, Berlin, Germany.
³ Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Medizinische Klinik für Gastroenterologie, Infektiologie und Rheumatologie, Berlin, Germany; The Transregio 241 IBDome Consortium, Berlin, Germany; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, iPATH.Berlin, Berlin, Germany.
⁴ Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany; The Transregio 241 IBDome Consortium, Berlin, Germany; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.
⁵ Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany; The Transregio 241 IBDome Consortium, Berlin, Germany. Electronic address: christoph.becker@uk-erlangen.de.
⁶ Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany; Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
⁷ Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany; College of Veterinary Medicine, Northeast Agricultural University, Harbin, People's Republic of China.
⁸ Department of Infection Biology, University Hospital Erlangen, Erlangen, Germany.
⁹ Department of Medicine 1, University of Erlangen-Nuremberg, Erlangen, Germany; Deutsches Zentrum Immuntherapie (DZI), Erlangen, Germany.

No abstract available

Publication types

Comparative Study

MeSH terms

Angiotensin-Converting Enzyme 2 / genetics
Angiotensin-Converting Enzyme 2 / metabolism*
Animals
COVID-19 / enzymology*
COVID-19 / virology
Case-Control Studies
Colitis, Ulcerative / enzymology
Colitis, Ulcerative / immunology
Colitis, Ulcerative / microbiology
Crohn Disease / enzymology*
Crohn Disease / genetics
Crohn Disease / immunology
Crohn Disease / microbiology
Disease Models, Animal
Down-Regulation
Gastrointestinal Microbiome*
Host-Pathogen Interactions
Humans
Ileum / enzymology*
Ileum / immunology
Ileum / microbiology
Inflammation Mediators / metabolism*
Mice
Mice, Knockout
Receptors, Virus / metabolism*
SARS-CoV-2 / enzymology*
SARS-CoV-2 / pathogenicity
STAT Transcription Factors / genetics
STAT Transcription Factors / metabolism
Serine Endopeptidases / metabolism
Signal Transduction
Toll-Like Receptors / genetics
Toll-Like Receptors / metabolism

Substances

Inflammation Mediators
Receptors, Virus
STAT Transcription Factors
Toll-Like Receptors
ACE2 protein, human
Ace2 protein, mouse
Angiotensin-Converting Enzyme 2
Serine Endopeptidases
TMPRSS2 protein, human