Objective: There is a high inter-individual variation in atorvastatin response. This study aimed to identify the influences of the CYP7A1 rs3808607, ABCG8 rs11887534, and ABCG8 rs4148217 genetic variants on the lipid profile and atorvastatin response among Arab Jordanian patients with type 2 II diabetes mellitus (T2DM).
Materials and methods: 117 patients with T2DM and on atorvastatin therapy, the most common statin used at the University of Jordan Hospital, were genotyped for the CYP7A1 rs3808607, ABCG8 rs11887534, and ABCG8 rs4148217 genetic variants using PCR-restriction fragment length polymorphism. The baseline blood lipid and glycemic parameters were analyzed in the University of Jordan Hospital's laboratory before and after 3 months of atorvastatin administration.
Results: Patients carrying the homozygote ABCG8 rs4148217 genotype have less total cholesterol (TC) (157.7 mg/dL) and low-density lipoprotein (LDL) (95.5 mg/dL) than the wild genotype (TC (192.4 mg/dL) and LDL (138.3 mg/dL)). Although these differences did not reach statistical significance (ANOVA, p-value > 0.17). There were no significant associations between the CYP7A1 rs3808607 and ABCG8 rs11887534 polymorphisms and baseline lipid and glycemic parameters (p > 0.12). Overall, no significant association was found between these polymorphisms and atorvastatin response (p > 0.13).
Conclusion: It seems that the CYP7A1 rs3808607, ABCG8 rs11887534, and ABCG8 rs4148217 genetic variants do not explain the inter-individual variation in atorvastatin response and lipid baseline profile among Jordanian T2DM patients of Arabic origin.