The Possible Dual Role of the ACE2 Receptor in Asthma and Coronavirus (SARS-CoV2) Infection

Front Cell Infect Microbiol. 2020 Sep 23:10:550571. doi: 10.3389/fcimb.2020.550571. eCollection 2020.

Authors

Anna Cláudia Calvielli Castelo Branco^{1

2}, Maria Notomi Sato², Ricardo Wesley Alberca²

Affiliations

¹ Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
² Laboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, School of Medicine and Institute of Tropical Medicine of São Paulo, University of São Paulo, São Paulo, Brazil.

No abstract available

Keywords: ACE2; COVID 19; SARS-CoV2; asthma; inflammation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Angiotensin-Converting Enzyme 2
Anti-Asthmatic Agents / therapeutic use
Asthma / complications*
Asthma / drug therapy
Asthma / pathology
Betacoronavirus / immunology
COVID-19
Coronavirus Infections / complications*
Coronavirus Infections / drug therapy
Coronavirus Infections / pathology
Cytokine Release Syndrome / blood
Cytokine Release Syndrome / pathology
Cytokines / blood
Eosinophils / immunology
Gene Expression Regulation / physiology
Humans
Lung / pathology*
Lung / virology
Pandemics
Peptidyl-Dipeptidase A / metabolism*
Pneumonia, Viral / complications*
Pneumonia, Viral / drug therapy
Pneumonia, Viral / pathology
Pulmonary Disease, Chronic Obstructive / complications*
Pulmonary Disease, Chronic Obstructive / pathology
SARS-CoV-2
Th2 Cells / immunology

Substances

Anti-Asthmatic Agents
Cytokines
Peptidyl-Dipeptidase A
ACE2 protein, human
Angiotensin-Converting Enzyme 2