The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis

J Charostad; M Nakhaie; A Dehghani; E Faghihloo

doi:10.1186/s13027-020-00317-4

The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis

Infect Agent Cancer. 2020 Oct 15:15:62. doi: 10.1186/s13027-020-00317-4. eCollection 2020.

Authors

J Charostad^{1

2}, M Nakhaie^{1

3}, A Dehghani¹, E Faghihloo⁴

Affiliations

¹ Department of Medical Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
² Department of Microbiology, Shahid Sadoghi University of Medical Science, Yazd, Iran.
³ Department of Medical Microbiology, Kerman University of Medical Sciences, Kerman, Iran.
⁴ Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Among the DNA tumor viruses Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), account for a considerable percentage of virus-associated cancers. Deregulation of transcription factors signaling pathways is one of the most significant oncogenic characteristics of EBV and KSHV. NF-κB is a transcription factor that play a remarkable role in oncogenesis because of its function as a master regulator of a spectrum of genes involved in physiological and pathophysiological process. Constitutive activation of NF-κB is a frequent and well-described event in many human malignancies. Compelling evidence represent EBV and KSHV are capable of targeting different components of NF-κB cascade. Here, we summarized recent findings to clarify the precise relationship between dysregulation of NF-κB and EBV and KSHV-related malignancies. This essay also emphasizes on contribution of various viral products in developing cancer through alteration of NF-κB signaling pathway.

Keywords: EBV; KSHV; NF-κB; Neoplasm.

Publication types

Review