Primary intraosseous meningioma of the calvarium: A systematic review

Oluwaseun A Omofoye; Trong Huynh; Ray Jhun; Hasan Ashfaque; Katharine Cronk

doi:10.1016/j.clineuro.2020.106283

Primary intraosseous meningioma of the calvarium: A systematic review

Clin Neurol Neurosurg. 2020 Dec:199:106283. doi: 10.1016/j.clineuro.2020.106283. Epub 2020 Oct 6.

Authors

Oluwaseun A Omofoye¹, Trong Huynh², Ray Jhun³, Hasan Ashfaque⁴, Katharine Cronk⁵

Affiliations

¹ Boston Medical Center, Department of Neurosurgery, 725 Albany Street 7c, Boston, MA, 02118, USA. Electronic address: oluwaseun.omofoye@cshs.org.
² Boston Medical Center, Department of Neurosurgery, 725 Albany Street 7c, Boston, MA, 02118, USA. Electronic address: th556@njms.rutgers.edu.
³ Boston University School of Medicine, 72 East Concord Street, Boston, MA, 02118, USA. Electronic address: rsjhun@bu.edu.
⁴ Boston Medical Center, Department of Neurosurgery, 725 Albany Street 7c, Boston, MA, 02118, USA. Electronic address: hasan.ashfaque@steward.org.
⁵ Boston Medical Center, Department of Neurosurgery, 725 Albany Street 7c, Boston, MA, 02118, USA. Electronic address: drkatecronk@gmail.com.

PMID: 33069929
DOI: 10.1016/j.clineuro.2020.106283

Abstract

Background: Primary intraosseous meningiomas (PIM) of calvarial origin are a small subset of meningiomas that arise from and occur within the calvarial bone. Its definition is often confused with other forms of non-dural based intracranial meningiomas, which has made previously published retrospective reviews heterogenous, non-specific and sometimes inaccurate. We present a systematic review of calvarial PIM.

Methods: Using a systematic search protocol that included databases such as PubMed, Web of Science and Embase, we extracted all human studies on PIM published from inception to December 2017. This systematic review includes case reports and retrospective reviews that specifically described PIM.

Results: On review of 166 articles identified with the systematic search protocol, 69 articles were analyzed. These comprised of 64 case reports, 1 case series and 4 retrospective reviews. 111 patients with PIM of calvarial origin were analyzed, 58 % of which were females and 42 % males. The mean patient age was 51 years and the frontal bone was the most common tumor location, occurring in 26.1 % of the cases. Surgical resection was the predominant modality of treatment in 97.2 % of the cases, and gross total resection was achieved in 84 % of cases that reported extent of resection. There were no recurrences for grade I meningiomas. However, all grade III meningiomas recurred and 33.3 % of grade II meningiomas showed recurrence with a mean postoperative follow-up interval of 20 months. Statistical analysis using Fisher's exact test showed the recurrence rate to be strongly associated with WHO tumor grade (p-value <0.001).

Conclusion: There is statistically significant increased recurrence rate for calvarial PIM of higher grades, and we recommend close follow-up in those cases. Surgical resection remains the overwhelming treatment of choice for calvarial PIM, and it has a high gross total resection rate and low risk of complications and mortality.

Keywords: Intraosseous; Meningioma; Meta-analysis; Systematic review.

Publication types

Case Reports
Systematic Review

MeSH terms

Humans
Magnetic Resonance Imaging / methods
Meningeal Neoplasms / diagnostic imaging*
Meningeal Neoplasms / therapy
Meningioma / diagnostic imaging*
Meningioma / therapy
Retrospective Studies
Skull / diagnostic imaging*
Skull Neoplasms / diagnostic imaging*
Skull Neoplasms / therapy
Tomography, X-Ray Computed / methods