HATtracting Nucleases to Stalled Forks

Giuseppe Leuzzi; Angelo Taglialatela; Alberto Ciccia

doi:10.1016/j.molcel.2020.09.031

HATtracting Nucleases to Stalled Forks

Mol Cell. 2020 Oct 15;80(2):177-180. doi: 10.1016/j.molcel.2020.09.031.

Authors

Giuseppe Leuzzi¹, Angelo Taglialatela¹, Alberto Ciccia²

Affiliations

¹ Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, USA.
² Department of Genetics and Development, Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, USA. Electronic address: ac3685@cumc.columbia.edu.

PMID: 33065018
DOI: 10.1016/j.molcel.2020.09.031

Abstract

In this issue of Molecular Cell, Kim et al., 2020 report that PCAF is a fork-associated histone acetyltransferase (HAT) that regulates the stability of stalled forks and the response to PARP inhibition in BRCA1/2-deficient cells.

Publication types

Comment

MeSH terms

Acetylation
DNA Replication*
Endonucleases
Histones*

Substances

Histones
Endonucleases