Use of therapeutic plasma exchange for pediatric neurological diseases

Tina S Ipe; Erin K Meyer; Kimberly W Sanford; Sarita K Joshi; Edward C C Wong; Jay S Raval

doi:10.1002/jca.21850

Use of therapeutic plasma exchange for pediatric neurological diseases

J Clin Apher. 2021 Feb;36(1):161-176. doi: 10.1002/jca.21850. Epub 2020 Oct 16.

Authors

Tina S Ipe¹, Erin K Meyer^{2

3}, Kimberly W Sanford⁴, Sarita K Joshi⁵, Edward C C Wong^{6

7}, Jay S Raval⁸

Affiliations

¹ Department of Pathology and Laboratory Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
² American Red Cross, Columbus, Ohio, USA.
³ Department of Pathology, Nationwide Children's Hospital, Columbus, Ohio, USA.
⁴ Department of Pathology, Virginia Commonwealth University, Richmond, Virginia, USA.
⁵ Department of Hematology/Oncology and Bone Marrow Transplant, University of Washington, Seattle, Washington, USA.
⁶ Department of Pediatrics and Pathology, George Washington School of Medicine and Health Sciences, Washington, District of Columbia, USA.
⁷ Department of Pathology, University of New Mexico, Albuquerque, New Mexico, USA.
⁸ Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, North Carolina, USA.

PMID: 33063869
DOI: 10.1002/jca.21850

Abstract

Therapeutic plasma exchange is used to treat neurological diseases in the pediatric population. Since its first use in pediatric patients with hepatic coma in the form of manual whole blood exchange, therapeutic plasma exchange has been increasingly used to treat these disorders of the nervous system. This expansion is a result of improved techniques and apheresis instruments suitable for small children, as well as the recognition of its applicability to many diseases in the pediatric population. This review provides a historical overview of the use of therapeutic apheresis in children and highlights the most common applications for therapeutic plasma exchange to treat neurological disorders in children.

Keywords: TPE; neurological diseases; pediatric.

Publication types

Review

MeSH terms

Child
Encephalomyelitis / therapy
Guillain-Barre Syndrome / therapy
Humans
Lambert-Eaton Myasthenic Syndrome / therapy
Myasthenia Gravis / therapy
Nervous System Diseases / therapy*
Neuromyelitis Optica / therapy
Plasma Exchange / methods*
Receptors, N-Methyl-D-Aspartate / immunology
Streptococcal Infections / complications
Thyroiditis, Autoimmune / complications

Substances

Receptors, N-Methyl-D-Aspartate